The Goose That Laid the Golden Egg: Accutane - the Truth That Had to Be Told, by Doug Bremner
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The Goose That Laid the Golden Egg: Accutane - the Truth That Had to Be Told, by Doug Bremner
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In 2001 Hoffmann-La Roche's drug Accutane was selling in the billions worldwide as a treatment for acne. For those who suffered from extreme, scarring acne, it was something of a miraculous treatment; however evidence started to mount that for others it was a death sentence. Over the next few years, it was estimated that between 300 and 3,000 young people being prescribed Accutane since its launch had committed suicide. Dr. Doug Bremner, a professor of psychiatry and radiology at Emory University, found that the drug did have an effect on the brain likely to cause acute depression in some patients, which was not surprising as it is a molecular cousin of Vitamin A, which is known to cause depression in excessive quantities. One might think the drug company would have welcomed these findings. You might like to think again on that one. The Goose That Laid The Golden Egg is the account of what Hoffmann-La Roche did next, which was to prosecute a determined, energetic, and vindictive campaign against Dr. Bremner, designed to suppress his findings and destroy his career and livelihood. Knowing that the life of a whistleblower is rarely a happy one, why did Dr. Bremner decide to take anything that Hoffman-La Roche could throw at him rather than back down?
It could be that he had a strong belief that the public should be well informed about the side effects of drugs in order to be able to make an objective decision, but maybe there was also a more emotional one stretching back to an equally determined, energetic, and vindictive web of secrecy based on a pivotal and traumatic event in his childhood, which he was also determined to get to the bottom of. From the pen of the author of Before You Take That Pill: Why the Drug Industry May Be Bad for Your Health, this is a truly riveting and emotional listen detailing just what it costs to take on the full might of one of the largest corporations in the world.
The Goose That Laid the Golden Egg: Accutane - the Truth That Had to Be Told, by Doug Bremner - Amazon Sales Rank: #160399 in Audible
- Published on: 2015-03-12
- Format: Unabridged
- Original language: English
- Running time: 289 minutes
The Goose That Laid the Golden Egg: Accutane - the Truth That Had to Be Told, by Doug Bremner
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Most helpful customer reviews
15 of 15 people found the following review helpful. Review of "The Goose That Laid the Golden Egg" By Garry Wilson I just finished reading "The Goose That Laid The Golden Egg." I enjoyed it very much. What a journey Doug had. I should not have been surprised at how many medical and drug company professionals turned a blind eye to a dangerous drug for personal gain; but I was. I think most of us still believe most doctors and especially psychiatrists are altruistic. I guess doctors are not immune from human nature: people are reluctant to "kill the golden goose." I was also surprised that a major reputable drug company would continue to push a drug that might be leading to suicide. Even if you don't expect them to take a suspect drug off the market on moral grounds, selling drugs that may be killing people is very bad for business. After all, trust and Goodwill are fundamental to long term success. In this story Doug reminded me of Don Quixote: not a knight by profession, but someone who could not tolerate the way some scoundrels were treating Dulcinea -- who, by the way turns out to be much more than a metaphor in this story; but I don't want to ruin the surprise. Sometimes life presents us with real dragons. Maybe it's only then we find out what we're made of.
9 of 10 people found the following review helpful. Profile in Courage By Bob Sims This isn't your typical science book. It's not stodgy or boring. It's a story about the lucrative drug industry, the FDA, and sophisticated chemical and psychological research in the scientific sense, sure. But, this book, "The Goose That Laid The Golden Egg," reads like a good mystery novel that happens to be true. It is an unflinchingly honest story of one man fighting an unscrupulous multibillion-dollar corporation -- with all its attendant skulduggery, cover-up attempts and threats to his family. But, what this book is, really, is a very moving, personal journey of self-discovery, akin to Thomas Paine's "a trial that tested men's souls." In this case, the trial is Dr. Doug Bremner's. Bremner is an Emory University Professor of Psychiatry and Radiology who, in his research, discovers drug company Hoffman-La Rouche Laboratories' hot-selling "miracle drug" Accutane -- a medication for acne -- is not only being over-prescribed to teens, but is also a "causal link" for depression and suicides in alarming numbers in that age group. Bremner bucks the tide of his money-grubbing, yes-men, academic-peer researchers and tells the truth when he discovers that Accutane is a very, very dangerous drug in his research. Bremner, then too, becomes dangerous: He is affecting the bottom line of a giant corporation. The corporation, Hoffman-La Rouche, goes on the warpath to defend their questionable practices, pursuing every legal avenue to protect themselves, even going so far as to attack Bremner's squeaky-clean credibility. Bremner, one who normally shies away from controversy, remains true to himself and refuses to yield. Bremner puts his personal life on trial in the process, too, questioning his own beliefs and fears -- centered around the sparse history of his deceased mom. His mom died unexpectedly when he was four years old, leaving Bremner with lingering anguish well into adulthood from the lack of closure and reasons why. In the face of growing legal pressure from Hoffman-La Rouche, Bremner begins his Odyssey to discover and honor his mother's past. In the end, Bremner's courageous personal journey also leads him to a successful outcome against Hoffman-La Rouche. In the telling of this story, Dr. Bremner's voice resonates for all the young people who most likely died from this drug's effects and prevents any more kids from being lost because of it. "You know I've seen a lot of people walking around with tombstones in their eyes. But the pusher don't care if you live -- or you die. God damn the pusher man (written by Hoyt Axton, sung by Steppenwolf, 1969)."
5 of 5 people found the following review helpful. Frightening, moving, personal and redemptive. By Timothy Murphy, MD Dr Bremner has written a moving account weaving together his personal struggles of loss and shame, with the professional struggles he faces in mid-career when a large pharmaceutical firm goes on the offensive to discredit his research, which threatens the profits they are making on Accutane.As a research physician, I have been lucky to have avoided the pitfalls Dr. Bremner faced. But the profits made on medications are driving the research almost entirely now, and that financial concern will inevitably force patient safety to the rear. I remember a research scientist with a large international firm telling me that the profits associated with the antibiotic I was researching - amounting to some 300 million a year - was "like the money left over in your office coffee fund at the end of the month" in the view of the controlling pharmaceutical company. It was then that I started to grasp the scale of profits that they are interested in and how they make choices about drugs.When Dr. Bremner started to look into the neurologic changes in the brain associated with Accutane, he met determined resistance from colleagues, and the industry. This then turned into personal and professional attacks on his integrity and his science itself. The extent of the steps that Roche took to ruin his career are stunning, and will serve as a warning shot to any other scientist considering facing them down. The degree of direct and immoral complicity in that attack by members of the academic faculty are equally stunning.But unlike the movies, where the hero just bravely and boldly takes on the big bad boys (win or lose), this narrative moves instead into a honest account of how terrifying this really is. The honesty in the book is stunningly clear, straightforward and blunt. Dr. Bremner is unsparing in detailing his own personal failings in coping with the stress of being attacked in such a personal and vicious manner.As he struggles with a tendency to withdraw into fantasy, he begins to connect how his personal struggle in coping with the attacks by Roche is influenced by his unresolved grief over the loss of his mother. He details how he gradually started to look for her story - covered up and denied by his surviving father and step-mother - and how that search finally leads him to a healing place. It is so clear that he had to go straight into his pain, to be able to deal with his marital and professional struggles.This book details perfectly the personal struggles one would face who had lost a parent at a very young age. It exposes the fraudulent and decadent practices of the high-flying academic physicians who are sometimes in the pocket of Big Pharma. The book details how we can retreat into fantasy to numb our pain, but also how facing it heals our pain. It shows us how poorly families can deal with death and loss, often for the simple reason that they did not know any better - even smart folks like psychiatrists.This book is a riveting and excellent read - I read it in one sitting. I highly recommend it.Tim Murphy
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The Goose That Laid the Golden Egg: Accutane - the Truth That Had to Be Told, by Doug Bremner
The Goose That Laid the Golden Egg: Accutane - the Truth That Had to Be Told, by Doug Bremner
